Neurological damage caused by Parkinson’s, Alzheimer’s and Huntington’s could be ‘reversed’, say scientists

Astonishing research conducted by Leicester University has shown that detrimental neurological damage caused by the likes of Parkinson’s, Alzheimer’s and Huntington’s diseases can potentially be ‘reversed’.

The news comes after University experiments using fruit flies found that lower levels of toxic metabolites in the nervous system could lessen several symptoms of neurodegeneration.

Scientists gave fruit flies a chemical containing an intelligent enzyme (TDO) which regulated the relationship between unbalanced neurotoxins – Kynurenic acid (KYNA) and 3-hydroxykynurenine (3-HK) – the former of which prevents nerve cell degeneration and the latter of which promotes it.

Study co-author, Carlo Breda, from Leicester University, said: “A key finding of our study is that we can improve ‘symptoms’ in fruit fly models of Alzheimer’s and Parkinson’s disease by feeding them a drug-like chemical.

“Our experiments have identified TDO as a very promising new drug target“.

Professor Giorgini, from Leicester University, said: “The two most common neurodegenerative disorders worldwide are Alzheimer’s and Parkinson’s disease.

“The treatment options for these diseases are limited, and to date no cures exist.

“Our hope is that by improving our knowledge of how these nerve cells become sick and die in the brain, we can help devise ways to interfere with these processes, and thereby either delay disease onset or prevent disease altogether.”